Fabian M. Kiessling

Nanoparticle size governs engagement with myeloid cells and hitchhiking to hematopoietic organs in myeloproliferative neoplasms

This study shows that nanoparticle size affects their uptake by myeloid cells and delivery to hematopoietic organs in myeloproliferative neoplasms.

Melatonin nanoparticles inhibit mutant hematopoiesis and restore bone marrow architecture in myeloproliferative neoplasms

This study shows that melatonin nanoparticles reduce myeloproliferative neoplasm symptoms by targeting metabolic, inflammatory, and fibrotic pathways.

Oncodevelopmental plasticity of the skeleton in myeloid neoplasms

This study identifies a novel mechanism in myelofibrosis where a single mutation drives both bone formation and resorption, revealing THBS1 as a therapeutic target.

Wnt-dependent spatiotemporal reprogramming ofbone marrow niches drives fibrosis

The paper shows that Wnt-dependent reprogramming of bone marrow niches drives fibrosis by activating osteolineage cells and altering hematopoietic support.

Intercellular adhesion molecule-1 protects against adipose tissue inflammation and insulin resistance but promotes liver inflammation and hepatic fibrosis in mice

This study shows ICAM-1 protects against adipose tissue inflammation and insulin resistance but worsens liver inflammation and fibrosis in mice with diet-induced obesity.

Breaking Medical Data Sharing Boundaries by EmployingArtificial Radiographs

This paper introduces a method to generate high-resolution artificial radiographs using generative models to overcome data sharing barriers in medicine.