The splicing paralogues SNRPB and SNRPN control differential metabolic states.
Feyza Polat Haas, Ana Villalba, Polina Rusina, Anusha B. Gopalan, Hector Fritz, Azamat Akhmetkaliyev, Frank Rühle, Anna Einsiedel, Anna Szczepińska, Fridolin Kielisch, Jia-Xuan Chen, Susanne Nguyen, Thierry Schmidlin, Simon Hippenmeyer, Maria Felicia Basilicata, Claudia Isabelle Keller Valsecchi
The paper shows SNRPN, a paralogue of SNRPB, stabilizes metabolic transcripts and enhances mitochondrial function, revealing a methylation-dependent mechanism for metabolic specialization in mammals.
bioRxiv · Feb 11, 2026 · PreprintMolecular Biology