Simon Hippenmeyer

The paper identifies a human-specific transcriptomic deletion in HMMR that affects cell division plasticity and links cortical expansion to cancer risk.

This study investigates the role of Pten in radial glial progenitor lineage progression and astrocyte production during cortical development, finding that Pten loss increases astrocyte generation and disrupts growth factor signaling.

This study investigates the role of Mtor/Rptor in cortical development, finding that its loss causes microcephaly through tissue-wide effects, while cell-autonomous Rptor function is critical for postnatal neuron survival in a cell-type-specific manner.

This study traces the lineage of spinal cord progenitors in mice to show that individual progenitors can generate diverse neuron and astrocyte types, challenging the idea of fixed progenitor identities.

The paper shows SNRPN, a paralogue of SNRPB, stabilizes metabolic transcripts and enhances mitochondrial function, revealing a methylation-dependent mechanism for metabolic specialization in mammals.

This study identifies cell competition as a key driver of gliomagenesis by showing that pre-malignant OPCs outcompete wildtype cells, and inhibiting this process reduces tumor growth.

The paper challenges the established model of cortical neurogenesis by showing indirect neurogenesis predominates early and shifts to direct neurogenesis later in mouse cerebral cortex development.

The paper reveals that early multipotent radial glial progenitors generate all projection neurons through parallel sublineages and fate-restricted daughter cells, challenging existing models of cortical development.

This study shows FOXG1 regulates gliogenesis in the mouse neocortex through distinct roles in progenitors and postmitotic neurons, modulating the FGF signalling pathway to control astrocyte and oligodendrocyte production.

This study identifies multipotent progenitors in the superior colliculus that generate all excitatory and inhibitory neuron types without extrinsic input.

The paper investigates how changes in large neutral amino acid metabolism during development affect neuronal excitability and survival, finding that Slc7a5 deletion disrupts lipid metabolism and leads to long-term circuit dysfunction.

The paper shows PRC2 has distinct, sequential functions in RGP lineage progression, acting tissue-wide for proliferation and cell-autonomously for astrocyte maturation.

This study shows that tissue-wide genetic effects override cell-intrinsic gene function in cortical neuron migration using MADM and single-cell analysis.

The paper introduces a genome-wide MADM mouse library enabling single-cell genetic mosaic analysis and uses it to study chromosome-specific segregation biases in stem cell division.

The paper shows that Notch signaling regulates the fate of cerebellar progenitors to generate both excitatory and inhibitory neurons.

The paper uses scRNA-seq data from mouse brain cortex to identify cell types and lineages by analyzing LOH events and gene expression patterns.

This study shows that GluD2 and Cbln1 mediate competitive synaptogenesis, shaping Purkinje cell dendritic arbors in the cerebellum through competitive synapse formation.

The paper identifies novel imprinted genes in mouse blastocysts and shows that their expression is mostly independent of DNA methylation but associated with H3K27me3 marks.

This study shows that blood vessel regression in the brain reduces neuronal activity by impairing mitochondrial metabolism and glutamate production.

The paper shows LIS1 regulates cleavage plane positioning by controlling actomyosin-mediated cell membrane contractility in neural progenitor cells.

The paper quantifies progenitor cell outputs in the developing mouse neocortex, showing stochastic lineage generation of pyramidal cells leading to diverse laminar configurations.