Structural studies of mycobacterial HptG reveal a silent state and offer insights into TLR4 activation
Giovanni Barra, Marina Sala, Maria Carmina Scala, Pietro Campiglia, Hwa‐Jung Kim, Alessia Ruggiero, Rita Berisio
This study presents the first crystal structure of HtpGMtb, revealing a conformationally silent dimer and direct TLR4 interaction, providing insights into its catalytic activity and TLR4 activation mechanism.
bioRxiv · Dec 11, 2025 · PreprintBiophysics