NAD+ - and EVA1-C-dependent reversal of neurological deficits is mediated by differential alternative RNA splicing in tauopathic animal models
Ruixue Ai, Lipeng Mao, Xurui Jin, Shiqi Zhang, Junping Pan, Mariá José Lagartos-Donate, Shuqin Cao, Guang Yang, Chenglong Xie, Xiongbin Kang, Pingjie Wang, Yang Hu, Linda Hildegard Bergersen, Jon Storm‐Mathisen, Hidehito Kuroyanagi, , Evandro Fei Fang
The paper shows NAD+ and EVA1-C regulate alternative splicing in tauopathies, affecting protein interactions and disease progression, suggesting therapeutic potential for AD.
bioRxiv · Oct 27, 2024 · PreprintNeuroscience