Cancer BiologyCancer LettersPeer-reviewed
Targeting the Mitochondrial ACSS1 Dependent Acetate and Pyrimidine Axis Suppresses Mantle Cell Lymphoma Progression
Johnvesly Basappa, Aaron R. Goldman, Cosimo Lobello…·Mariusz A. Wasik
This paper identifies ACSS1 as a metabolic driver in lymphomas, showing its role in acetate-to-acetyl-CoA conversion and pyrimidine biosynthesis, and demonstrates that targeting ACSS1 suppresses tumor growth.
2 citations