Hossein Borghaei

This paper identifies ACSS1 as a metabolic driver in lymphomas, showing its role in acetate-to-acetyl-CoA conversion and pyrimidine biosynthesis, and demonstrates that targeting ACSS1 suppresses tumor growth.

This study shows ATM regulates metabolic stress in SCLC by affecting ATF4 and MYC, leading to ferroptotic cell death and revealing a new therapeutic target.