Daniel DeBord

This paper introduces PAMAF, a novel DIA-MS mode using HRIM for proteomics, achieving higher sensitivity and efficiency in protein identification and quantification.

xTracer identifies peptides in PAMAF data by integrating chromatogram and mobiligram correlations, improving identification accuracy over single-domain methods.

This study uses PAMAF mode HRIM-MS to quantify succinylation sites in mouse kidney, showing Sirt5 regulates succinylation of mitochondrial proteins involved in metabolism.

This paper introduces high resolution ion mobility (HRIM) as a faster and more sensitive alternative to quadrupole mass spectrometry for fragmentation analysis, achieving up to 1,000 Hz speeds with 100% ion utilization.