Eric S. Goetzman

This paper shows that a Humanin analogue improves cardiac function and reduces remodeling in ischemic hearts by promoting metabolic reprogramming from fatty acids to glucose.

This paper introduces 4D Oxy-wavelet MRI to non-invasively assess mitochondrial function in living brains across the lifespan, validated in mouse models and with human feasibility data.

This study uses PAMAF mode HRIM-MS to quantify succinylation sites in mouse kidney, showing Sirt5 regulates succinylation of mitochondrial proteins involved in metabolism.

The paper shows that dissociation of mitochondrial Complex V into Fo and F1 domains balances anabolic and energy needs in cancer cells by uncoupling ATP synthesis from TCA cycle activity.

This study shows that feeding mice odd-chain dicarboxylic acids reproduces the biochemical features of glutaric aciduria type-1.

This study investigates systemic metabolic changes in a mouse model of left ventricular hypertrophy, finding that exogenous long-chain fatty acid supplementation improves mitochondrial function but does not fully reverse the disease phenotype.

This study shows that oral octanoylcarnitine improves exercise tolerance and reduces metabolic stress in mouse models of long-chain fatty acid oxidation disorders.

This study shows Adropin treatment reverses cardiac dysfunction and metabolic defects in a mouse model of HFpEF by reducing O-GlcNAcylation of LCAD and improving fatty acid oxidation.

This study shows that loss of LCAD protects against acute kidney injury by reducing oxidative stress and enhancing peroxisomal fatty acid oxidation.

Maternal administration of mitochondrial-targeted JP4-039 mitigates fetal brain injury and preserves mitochondrial function after mid-gestation radiation exposure.