TRPM4 Couples Mechanical Force to Myogenic Constriction Throughout the Resistance Vasculature
Wanchun Zhu, Alfredo Sanchez Solano, Boris J. Lavanderos…·Scott Earley
This study demonstrates that TRPM4 channels are essential for mechanotransduction in resistance arteries, mediating pressure-induced smooth muscle cell depolarization and myogenic constriction across cerebral, mesenteric, and skeletal muscle vessels.