John C. Panepinto

Yck2 links mitochondrial function and pH homeostasis to cell wall remodeling and antifungal susceptibility in Cryptococcus neoformans

This study identifies Yck2's role in linking mitochondrial function, pH homeostasis, and cell wall remodeling in Cryptococcus neoformans, revealing mechanisms behind its impact on antifungal susceptibility.

NMD-mediated control of Tor influences adaptation to nutrient and temperature conditions in Cryptococcus neoformans

This study shows NMD regulates Tor signaling in C. neoformans, affecting adaptation to nutrient and temperature conditions and fluconazole sensitivity.

Stress-responsive roles of the C. neoformans human-like eIF3 complex

This study investigates the role of eIF3 subunits in stress adaptation and pathogenesis of C. neoformans, showing sensitivity to mitochondrial stress and differential drug responses in specific mutants.

Hog1/p38 regulates the integrated stress response (ISR) and global transcriptomics changes in C. neoformans during oxidative stresschanges in C. neoformans during oxidative stress.

The paper investigates the role of Hog1/p38 and Gcn2 pathways in C. neoformans' response to oxidative stress, showing their convergence on transcriptomic changes and stress tolerance.

Gcn2 rescues reprogramming in the absence of Hog1/p38 signaling in C. neoformans during thermal stress.

This study shows that Gcn2 compensates for Hog1/p38 loss in C. neoformans during thermal stress, rescuing adaptation and virulence through crosstalk between these pathways.

Contributions of Ccr4 and Gcn2 to the translational response of C. neoformans to host-relevant stressors and Integrated Stress Response induction

This study examines how Ccr4 and Gcn2 pathways contribute to translational reprogramming in C. neoformans under host-relevant stressors, showing differential roles in oxidative stress and temperature stress.

Arginine methylation of Puf4 drives diverse protein functions

This study shows that arginine methylation of Puf4 regulates its functions in post-transcriptional gene regulation in Cryptococcus neoformans.