Michael G. Kharas

This study identifies mRNA glycation by methylglyoxal as a metabolic stress sensor, showing impaired translation and beta-cell dysfunction, which is mitigated by metformin.

The paper identifies a genetic variant that protects against clonal hematopoiesis by regulating RNA-binding protein MSI2 in hematopoietic stem cells.

This study identifies an epigenetically distinct HSC subset, Kitlo, that supports better thymic and T-cell reconstitution in mice and humans.

ChromaFold predicts 3D chromatin contact maps from scATAC-seq data, outperforming bulk-based methods and enabling cell-type-specific interaction analysis.

FLARE is a framework for fast and automatic detection of rare cell populations in flow cytometry data using hierarchical Bayesian models and parallel computation.