Yael David

This study identifies a dietary lipid axis driven by linoleic acid and FADS2 that suppresses antitumor immunity in liver cancer, offering a therapeutic target for immunotherapy resistance.

This study identifies mRNA glycation by methylglyoxal as a metabolic stress sensor, showing impaired translation and beta-cell dysfunction, which is mitigated by metformin.

This study identifies QR2 as a reader of H3Q5ser, showing its role in human neuron development through transcriptional and electrophysiological effects.

This study identifies a nucleosome switch that primes Hepatitis B Virus infection by driving X gene transcription and shows that CBL137 inhibits this process.

This study determines crystal structures of HsFN3K to elucidate its substrate recognition and kinase activity, providing insights for small molecule design targeting FN3K.

This study shows UHRF1 ubiquitin ligase activity and DNMT1 ubiquitin reading activity are essential for maintaining low-density CpG methylation, and their disruption leads to hypomethylation and PMD formation in cancer.

This study identifies H2BE as a widely expressed H2B variant that enhances chromatin accessibility in neurons, promoting synaptic gene expression and long-term memory.

A single enzyme, TGM2, bidirectionally controls H3 monoaminylation dynamics, which, in turn, facilitate neural rhythmicity.

This study shows that DOT1L regulates transcriptional initiation by facilitating TFIID recruitment and modulating H2B monoubiquitination, challenging its previously assumed role in transcriptional elongation.