Author

Julian R. Braxton

University of California, San FranciscoORCID 0000-0002-1170-5140Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Biochemistry· 1 Biophysics· 1 Molecular Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:protein folding & dynamics· 2 Research Focus:cell type annotation· 1 Assay:ChIP-seq· 1 Assay:cryo-EM· 1 Research Focus:gene regulatory network inference· 1 Organism:human· 1 Approach:microscopy & imaging analysis· 1

Frequent Co-Authors

Ahmed A. A. AmineiD· 1 shared Andrew Lim· 1 shared Arthur Alves de MeloiD· 1 shared Bassem Al‐SadyiD· 1 shared Bryan D. RyderiD· 1 shared Catherine TaniD· 1 shared Dana R Kennedy· 1 shared Daniel R. SouthworthiD· 1 shared

Activity by Year

2025-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 20 mutual co-author links

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1 shared paperMolecular Biology

Ahmed A. A. AmineORCID

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3 papers

Recent·Most cited

BiochemistrybioRxivPreprintMay 20, 2026

In situ molecular architecture of the mammalian sperm nuclear vacuole

Julian R. Braxton, Songrong Qu, Will M. Skinner…·Zhen Chen

The paper identifies components of mammalian sperm nuclear vacuoles using cryo-ET and AlphaFold docking, revealing proteasomes, PA200, and ferritin, and their structural roles.

DOI 10.64898/2026.05.18.725999

mousecryo-EM

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BiophysicsbioRxivPreprintApr 15, 2026

Resolving the Activation Mechanism of the Human 20S Proteasome

Bryan D. Ryder, N. Yan, Danna Trejos-Vidal…·Jason E. Gestwicki

This study identifies a conserved leucine in the C-terminus of proteasome activators as essential for gate opening of the human 20S proteasome, with structural and functional evidence supporting its role.

DOI 10.64898/2026.04.13.718244

humanexperimental assay

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Molecular BiologyNucleic Acids ResearchPeer-reviewedOct 22, 2025

Phosphorylation of HP1/Swi6 relieves competition with Suv39/Clr4 on nucleosomes and enables H3K9 trimethyl spreading.

Dana R Kennedy, Joël P.C. Lemiere, Ahmed A. A. Amine…·Bassem Al‐Sady

This study shows that phosphorylation of HP1/Swi6 reduces competition with Suv39/Clr4 by altering its nucleosome affinity and oligomerization, promoting H3K9me3 spreading in S. pombe.

4 citations

yeastChIP-seq

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