Author

Andrew Lim

University of Cambridge

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Bioinformatics· 1 Biophysics· 1 Cell Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Assay:bulk RNA-seq· 1 Research Focus:drug response / drug discovery· 1 Organism:human· 1 Research Focus:protein folding & dynamics· 1 Research Focus:software / tool· 1 Approach:statistical model· 1

Frequent Co-Authors

John SkidmoreiD· 2 shared Aldo S. BaderiD· 1 shared Arthur Alves de MeloiD· 1 shared Bryan D. RyderiD· 1 shared Christopher Alan Brown· 1 shared Daniel R. SouthworthiD· 1 shared Danna Trejos-VidaliD· 1 shared David Winpenny· 1 shared

Activity by Year

2024-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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2 shared papersCell Biology

John SkidmoreORCID

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Author profile →

3 papers

Recent·Most cited

A GCN1-independent activator of the kinase GCN2

Jiayi Zhu, Giulia Emanuelli, Glenn Robert Masson, Vanesa Vinciauskaite, Henriëtte M. G. Willems, Peiqiao Cai, Andrew Lim, Christopher Alan Brown, David Winpenny, Murray Clarke, Rebecca Gilley, Fergus Preston, Jordan Wilson, Aldo S. Bader, Taufiq Rahman, , Stefan John Marciniak

The paper identifies three GCN2 activators, one of which works independently of GCN1, and describes its unique binding mechanism.

eLife · Oct 27, 2026Peer-reviewedCell Biology

Resolving the Activation Mechanism of the Human 20S Proteasome

Bryan D. Ryder, N. Yan, Danna Trejos-Vidal, Patricia Martínez-Botía, Julian R. Braxton, Andrew Lim, Hannah Felstead, Steve Andrews, Eric Tse, Arthur Alves de Melo, John Skidmore, Miguel A. Prado, Daniel R. Southworth, Jason E. Gestwicki

This study identifies a conserved leucine in the C-terminus of proteasome activators as essential for gate opening of the human 20S proteasome, with structural and functional evidence supporting its role.

bioRxiv · Apr 15, 2026 · PreprintBiophysics

comrades-OO: An Object-Oriented R Package for Comprehensive Analysis of RNA Structure Generated using RNA crosslinking experiments

Jonathan L. Price, Omer Ziv, Malte L. Pinckert, Andrew Lim, Eric Alexander Miska

comradesOO is an R package for analyzing RNA structure data from COMRADES experiments, providing tools for processing, clustering, and comparing RNA structures and interactions.

Bioinformatics · Mar 29, 2024Peer-reviewedBioinformatics