Ruth Janke van Holst

Striatal ups or downs? Neural correlates of monetary reward anticipation, cue reactivity and their interaction in alcohol use disorder and gambling disorder

This study investigates striatal activation during reward anticipation with and without addiction-related cues in alcohol use disorder and gambling disorder, finding heterogeneous striatal dysfunction and cue-related behavioral interactions.

Metacognition and the effect of incentive motivation in two compulsive disorders: gambling disorder and obsessive-compulsive disorder

This study investigates metacognition and incentive motivation in gambling disorder and obsessive-compulsive disorder using fMRI, finding increased confidence in GD during gain contexts but no group differences in VMPFC activity.

How motivational signals disrupt metacognitive signals in the human VMPFC.

This study investigates how motivational signals affect metacognitive signals in the VMPFC during decision-making, finding that confidence signals are disrupted in trials with negative monetary prospects.

Altered orbitofrontal sulcogyral patterns in gambling disorder: a multicenter study

This study finds a skewed distribution of orbitofrontal sulcogyral patterns in gambling disorder, with increased prevalence of Type II patterns compared to healthy controls.

Spontaneous eye blink rate and dopamine synthesis capacity: Preliminary evidence for an absence of positive correlation

The paper investigates the relationship between spontaneous eye blink rate and striatal dopamine synthesis capacity using PET imaging and finds no positive correlation, suggesting caution in interpreting sEBR as a proxy for dopamine function.

Enhanced food-related responses in the ventral medial prefrontal cortex in orexin-deficient narcolepsy patients

This study finds that orexin-deficient narcolepsy patients show enhanced ventral medial prefrontal cortex responses to food words, which predicts increased snack intake.