William J. Jagust

Dopamine synthesis capacity and tau pathology differentially modulate rest-to-task functional network dynamics

This study examines how dopamine synthesis and tau pathology affect functional brain network dynamics during rest and task performance in young and older adults.

REM Sleep Misfires: Intruding Delta Waves Forecast Tau, Amyloid, and Forgetting in Aging

This study shows that aging and Alzheimer's disease are linked to changes in REM sleep delta waves, which are associated with memory decline and amyloid-beta and tau accumulation.

Tau pathology leads to lonely non-traveling slow waves that mediate human memory impairment

The paper shows that tau pathology in the frontal lobe impairs slow wave propagation, leading to memory deficits in humans.

Dopamine Compensates for Amyloid-Induced Default Mode Network Dysfunction to Support Learning

This study shows that dopamine compensates for amyloid-induced dysfunction in the default mode network to support learning in preclinical Alzheimer's disease.

Characterisation of Posterior Predominant Amyloid PET Binding Across Multiple Cohorts

This paper identifies a posterior predominant amyloid PET binding pattern in multiple cohorts, showing its clinical and biological relevance and suggesting the need for more nuanced analysis methods.

Neuropathologically validated MRI to tau PET synthesis via Covariate-modulated attention networks

The paper introduces CoMA-UNet, a method to synthesize tau PET from MRI using covariates, showing strong agreement with true PET and utility in clinical tasks.

Network-based amyloid-beta pathology predicts subsequent cognitive decline in cognitively normal older adults

This study uses machine learning to show that integrating brain connectome data with amyloid-beta PET imaging improves prediction of cognitive decline in older adults.

Temporal fMRI Dynamics Map Dopamine Physiology

The paper maps dopamine physiology using hemodynamic latency from fMRI, showing distinct patterns in the nucleus accumbens and linking them to addictive behaviors and substance use disorders.

Global brain activity and its coupling with cerebrospinal fluid flow is related to tau pathology

The paper links reduced coupling between cerebrospinal fluid flow and global brain activity to increased tau deposition and cognitive decline in Alzheimer's disease.

Imaging synaptic density in ageing and Alzheimer's Disease with -SynVesT-1

This study uses [18F]-SynVesT-1 PET to analyze synaptic density in aging and Alzheimer's Disease, finding associations with amyloid-beta, tau, and cognitive performance.

A dopaminergic basis of behavioral control

This study identifies distinct dopamine mechanisms for behavioral control and model-based knowledge formation using PET, fMRI, and pharmacological interventions.

Associations between regional blood-brain barrier disruption, aging, and Alzheimers disease biomarkers in cognitively normal older adults

Polygenic effects on the risk of Alzheimer's disease in the Japanese population

This paper evaluates the polygenic risk score for Alzheimer's disease in Japanese individuals, showing its utility despite genetic differences from European populations.

Defining overlooked structures reveals new associations between cortex and cognition in aging and Alzheimer's disease

The paper identifies tertiary sulci in the posterior medial cortex that show greater age and Alzheimer's disease-related thinning and are linked to cognitive functions like memory and executive function.

Striatal dopamine synthesis and cognitive flexibility differ between hormonal contraceptive users and non-users

This study compares dopamine synthesis and cognitive flexibility between hormonal contraceptive users and non-users using PET imaging and behavioral assessments.

Metacognition, cortical thickness, and tauopathy in aging

The paper examines metacognition measures and their links to cortical thickness and AD biomarkers in older adults, finding distinct associations with structural atrophy and tau pathology.

Altered excitatory and inhibitory neuronal subpopulation parameters are distinctly associated with tau and amyloid in Alzheimer's disease

The paper examines associations between neuronal subpopulation parameters and tau/A{beta} in AD patients using MEG and PET data.

Alzheimer's pathology is associated with dedifferentiation of functional memory networks in aging

The paper examines how age-related changes in brain network segregation correlate with Alzheimer's pathology and memory decline using fMRI and PET.

Predicting future regional tau accumulation in asymptomatic and early Alzheimer's disease

This study uses machine learning to predict future regional tau accumulation in asymptomatic and early Alzheimer's disease using multimodal data, showing improved accuracy over traditional measures.

Spread of pathological tau proteins through communicating neurons in human Alzheimer’s disease

This study uses an epidemic spreading model to show that tau spreads through neuronal connections in Alzheimer's disease, with beta-amyloid accelerating this process in some brain regions.

Multimodal Hippocampal Subfield Grading For Alzheimer’s Disease Classification

This study compares whole hippocampus and subfield biomarkers for Alzheimer’s disease detection and prediction using multimodal MRI data, finding subiculum biomarkers improve prediction accuracy.

A blood-based signature of cerebral spinal fluid Aβ1-42 status

This paper develops a blood-based machine learning model to predict cerebral spinal fluid Aβ1-42 levels, showing high accuracy in identifying Alzheimer's disease risk.

Uncovering the heterogeneity and temporal complexity of neurodegenerative diseases with Subtype and Stage Inference

This paper introduces SuStaIn, a machine learning method that identifies disease subtypes and their temporal progression from cross-sectional data, improving prediction of diagnostic conversion in neurodegenerative diseases.

Spontaneous eye blink rate and dopamine synthesis capacity: Preliminary evidence for an absence of positive correlation

The paper investigates the relationship between spontaneous eye blink rate and striatal dopamine synthesis capacity using PET imaging and finds no positive correlation, suggesting caution in interpreting sEBR as a proxy for dopamine function.