Valtteri Kaasinen

Stools and stool-derived extracellular vesicles from patients with Parkinson`s disease show alpha-4 synuclein seeding activity

This study shows that stool-derived extracellular vesicles from Parkinson's disease patients have alpha-synuclein seeding activity detectable by seed amplification assay, with improved sensitivity after pre-incubation with recombinant monomeric alpha-synuclein.

Striatal dopamine synthesis capacity in Parkinson's disease: Effects of age, sex, and body mass index in a large fluorodopa PET cohort

This study investigates how age, sex, and BMI affect striatal dopamine synthesis capacity in Parkinson's disease patients and healthy controls using PET data.

Seasonal variation in D2/3 dopamine receptor availability in the human brain

The paper investigates seasonal variation in D2/3 dopamine receptor availability in the human brain using PET scans and finds a negative correlation between daylength and receptor availability in the striatum.

Alterations in type 2 dopamine receptors across neuropsychiatric conditions: A large-scale PET cohort

This study examines D2R availability in neuropsychiatric conditions using PET data from 437 individuals, finding reduced availability in Parkinson's disease and altered interregional connectivity in schizophrenia, depression, and violent behavior.

Regulators of proteostasis are translationally repressed in fibroblasts from sporadic and LRRK2-G2019S Parkinson's patients

The paper identifies translational repression of proteostasis regulators in fibroblasts from both sporadic and LRRK2-G2019S Parkinson's patients using proteomics.

Resting state EEG as a biomarker of Parkinson's disease: Influence of measurement conditions

This study evaluates the use of resting state EEG for Parkinson's disease classification, finding that fewer electrodes and open-eye conditions improve accuracy.

Age and sex dependent variability of type 2 dopamine receptors in the human brain: A large-scale PET cohort

This study examines age and sex differences in striatal D2R availability using a large PET cohort, finding age-related decline and sex differences in D2R levels.

Cerebral μ-opioid and CB1-receptor systems have distinct roles in human feeding behavior

This study investigates the role of cerebral μ-opioid and CB1-receptor systems in human feeding behavior using PET scans and the Dutch Eating Behavior Questionnaire.

Cerebral grey matter density is associated with neuroreceptor and neurotransporter availability: A combined PET and MRI study

Seasonal variation in brain mu-opioid receptor availability

This study finds seasonal variation in brain mu-opioid receptor availability in humans, showing an inverted U-shaped relationship with daylength.

Protein synthesis is suppressed in sporadic and familial Parkinson's Disease by LRRK2

This study shows that LRRK2 activity suppresses protein synthesis in Parkinson's disease, with inhibition restoring normal translation in patient fibroblasts.

Deficits in monitoring self-produced speech in Parkinson's disease

The paper examines auditory evoked responses to self-produced and heard speech in Parkinson's disease patients, finding abnormal modulation in those without subjective speech deficits.

Interindividual variability and lateralization of μ-opioid receptors in the human brain

This study quantifies interindividual variability and hemispheric lateralization of μ-opioid receptors in the human brain using PET and Bayesian modeling.

Altered orbitofrontal sulcogyral patterns in gambling disorder: a multicenter study

This study finds a skewed distribution of orbitofrontal sulcogyral patterns in gambling disorder, with increased prevalence of Type II patterns compared to healthy controls.

Dopamine and eye movement control in Parkinson’s disease: deficits in corollary discharge signals?

This study investigates whether Parkinson’s disease patients have deficits in updating sensory representations after eye movements, linking these deficits to dopaminergic system integrity.