Wenhan Chen

Epigenetic therapy targets the 3D epigenome in endocrine-resistant breast cancer

This study shows that Decitabine suppresses tumour growth in ER+ breast cancer by inducing DNA hypomethylation and altering 3D chromatin structure.

mBAT-combo: a more powerful test to detect gene-trait associations from GWAS data

mBAT-combo improves gene-trait association detection in GWAS by accounting for SNP effect directions, revealing masking effects in complex traits.

Improved analyses of GWAS summary statistics by reducing data heterogeneity and errors

This paper introduces DENTIST, a method to reduce errors and heterogeneity in GWAS summary data, improving analyses like COJO and fine-mapping.

OSCA: a tool for omic-data-based complex trait analysis

OSCA provides a tool for omic-data-based complex trait analysis using the MOMENT method, showing improved robustness and lower false positive rates in simulations.

GtTR: Bayesian estimation of absolute tandem repeat copy number using sequence capture and high throughput sequencing

GtTR is a Bayesian method for estimating absolute tandem repeat copy numbers using targeted sequencing and reference data, achieving high accuracy in population-scale genotyping.

Profiling copy number alterations in cell-free tumour DNA using a single-reference

This paper introduces qCNV and sCNA-seq tools to profile somatic copy number alterations in cell-free DNA without a reference panel, showing effectiveness in detecting clinically relevant mutations from plasma samples.

sCNAphase: using haplotype resolved read depth to genotype somatic copy number alterations from low cellularity aneuploid tumors

sCNAphase improves copy number alteration analysis in low-cellularity tumors by using haplotype-resolved read depth to genotype somatic copy number alterations.