Author

James E. Cassat

Vanderbilt UniversityORCID 0000-0002-1199-1167Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

Click to filter author papers

Microbiology· 3 Immunology· 1

Signature Assays, Organisms & Methods

Click to filter · or open tag

Approach:experimental assay· 3 Research Focus:host-pathogen & immune response· 3 Organism:mouse· 3 Assay:bulk RNA-seq· 2 Research Focus:cell type annotation· 1 Organism:human· 1 Approach:statistical model· 1

Frequent Co-Authors

Brian M. PetersiD· 2 shared Deborah V. NovackiD· 2 shared Gabriel MbalavieleiD· 2 shared Kara R. EichelbergeriD· 2 shared Luke D O'ConnoriD· 2 shared Paul L. FideliD· 2 shared Saumya BhagatiD· 2 shared Bret R. SellmaniD· 1 shared

Activity by Year

2024-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 20 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

2 shared papersMicrobiology

Brian M. PetersORCID

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

MicrobiologyPLoS PathogensPeer-reviewedAug 5, 2026

Candida albicans activates Staphylococcus aureus virulence regulatory systems to drive toxin-mediated human cell death

Kara R. Eichelberger, R Chandrasekaran, Nicholas A Podar…·James E. Cassat

DOI 10.1371/journal.ppat.1014490

mouseexperimental assay

𝕏 PostBluesky

MicrobiologybioRxivPreprintMar 18, 2026

The osteoclast intracellular environment fosters bacterial growth during Staphylococcus aureus infection

Luke D O'Connor, Saumya Bhagat, Nidhi Roghati…·Deborah V. Novack

This study shows osteoclasts support S. aureus intracellular growth by providing nutrients and a blunted antimicrobial response.

DOI 10.64898/2026.03.18.712565

humanbulk RNA-seq

𝕏 PostBluesky

ImmunologybioRxivPreprintSep 24, 2025

Staphylococcus aureus inhibits the NLRP3 inflammasome in macrophages during the early phases of intracellular infection, but not the late phases

Saumya Bhagat, Khushpreet Kaur, Luke D O'Connor…·Gabriel Mbalaviele

This study shows S. aureus inhibits NLRP3 inflammasome activation in macrophages during early infection but not late infection, reducing bacterial load and pyroptosis.

1 citation

mouseexperimental assay

𝕏 PostBluesky

MicrobiologyNature CommunicationsPeer-reviewedJul 9, 2024

A fungal metabolic regulator underlies infectious synergism during Candida albicans-Staphylococcus aureus intra-abdominal co-infection

Saikat Paul, Olivia Adele Todd, Kara R. Eichelberger…·Brian M. Peters

This study identifies ZCF13 in Candida albicans as a regulator of ribose metabolism that enhances synergistic virulence with Staphylococcus aureus during intra-abdominal infection.

32 citationstop 1%

mousebulk RNA-seq

𝕏 PostBluesky