Author

Saumya Bhagat

Washington University in St. LouisORCID 0000-0001-8979-7455Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Immunology· 2 Microbiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Research Focus:host-pathogen & immune response· 2 Organism:mouse· 2 Assay:bulk RNA-seq· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Research Focus:development & morphogenesis· 1 Approach:genetic perturbation / CRISPR· 1

Frequent Co-Authors

Deborah V. NovackiD· 3 shared Gabriel MbalavieleiD· 3 shared Chun WangiD· 2 shared James E. CassatiD· 2 shared Khushpreet KauriD· 2 shared Kunjan KhannaiD· 2 shared Luke D O'ConnoriD· 2 shared Yongjia Li· 2 shared

Activity by Year

2025-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 42 mutual co-author links

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3 shared papersImmunology

Deborah V. NovackORCID

Mutual co-authors in cluster

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3 papers

Recent·Most cited

MicrobiologybioRxivPreprintMar 18, 2026

The osteoclast intracellular environment fosters bacterial growth during Staphylococcus aureus infection

Luke D O'Connor, Saumya Bhagat, Nidhi Roghati…·Deborah V. Novack

This study shows osteoclasts support S. aureus intracellular growth by providing nutrients and a blunted antimicrobial response.

DOI 10.64898/2026.03.18.712565

humanbulk RNA-seq

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ImmunologybioRxivPreprintSep 24, 2025

Staphylococcus aureus inhibits the NLRP3 inflammasome in macrophages during the early phases of intracellular infection, but not the late phases

Saumya Bhagat, Khushpreet Kaur, Luke D O'Connor…·Gabriel Mbalaviele

This study shows S. aureus inhibits NLRP3 inflammasome activation in macrophages during early infection but not late infection, reducing bacterial load and pyroptosis.

1 citation

mouseexperimental assay

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ImmunologybioRxivPreprintJul 28, 2025

NLRP3 inflammasome is regulated in osteoclasts through a Tmem178-dependent mechanism that restricts calcium influx

Khushpreet Kaur, Yael Alippe, Chun Wang…·Gabriel Mbalaviele

The paper shows Tmem178 suppresses NLRP3 inflammasome activation in osteoclasts by limiting calcium release, preventing excessive bone resorption.

DOI 10.1101/2025.07.28.667255

mouseproteomics

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