Pyroptotic cell-derived factors promote osteoclast differentiation
Yongjia Li, Chun Wang, 许灿新…·许灿新
This study shows that NLRP3CA-induced pyroptosis releases soluble proteins that promote osteoclast differentiation independently of IL-1β.
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Washington University in St. LouisORCID 0000-0002-8277-6114Unclaimed ORCID profile · follow to get notified of new preprints
4 papers
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Yongjia Li, Chun Wang, 许灿新…·许灿新
This study shows that NLRP3CA-induced pyroptosis releases soluble proteins that promote osteoclast differentiation independently of IL-1β.
Saumya Bhagat, Khushpreet Kaur, Luke D O'Connor…·Gabriel Mbalaviele
This study shows S. aureus inhibits NLRP3 inflammasome activation in macrophages during early infection but not late infection, reducing bacterial load and pyroptosis.
Khushpreet Kaur, Yael Alippe, Chun Wang…·Gabriel Mbalaviele
The paper shows Tmem178 suppresses NLRP3 inflammasome activation in osteoclasts by limiting calcium release, preventing excessive bone resorption.
Rinkle Sharma, Diksha Rana, Rahul Kumar…·Indu Verma
This study identifies gene expression changes and pathways involved in osteoarthritis progression using synovial fluid transcriptomes from different OA grades.