Author

Luke D O'Connor

Washington University in St. LouisORCID 0000-0002-9207-7237Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Immunology· 1 Microbiology· 1

Signature Assays, Organisms & Methods

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Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1 Approach:experimental assay· 1 Research Focus:host-pathogen & immune response· 1 Organism:human· 1 Organism:mouse· 1 Approach:statistical model· 1

Frequent Co-Authors

Deborah V. NovackiD· 2 shared Gabriel MbalavieleiD· 2 shared James E. CassatiD· 2 shared Saumya BhagatiD· 2 shared Chun WangiD· 1 shared Gaurav SwarnkariD· 1 shared Khushpreet KauriD· 1 shared Kunjan KhannaiD· 1 shared

Activity by Year

2025-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 40 mutual co-author links

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2 shared papersMicrobiology

Deborah V. NovackORCID

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2 papers

Recent·Most cited

MicrobiologybioRxivPreprintMar 18, 2026

The osteoclast intracellular environment fosters bacterial growth during Staphylococcus aureus infection

Luke D O'Connor, Saumya Bhagat, Nidhi Roghati…·Deborah V. Novack

This study shows osteoclasts support S. aureus intracellular growth by providing nutrients and a blunted antimicrobial response.

DOI 10.64898/2026.03.18.712565

humanbulk RNA-seq

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ImmunologybioRxivPreprintSep 24, 2025

Staphylococcus aureus inhibits the NLRP3 inflammasome in macrophages during the early phases of intracellular infection, but not the late phases

Saumya Bhagat, Khushpreet Kaur, Luke D O'Connor…·Gabriel Mbalaviele

This study shows S. aureus inhibits NLRP3 inflammasome activation in macrophages during early infection but not late infection, reducing bacterial load and pyroptosis.

1 citation

mouseexperimental assay

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