Li Tan

EasyPseudogene detects pseudogenes in eukaryotic genomes using an automated, multithreaded pipeline with inter-species reference-driven analysis and high-fidelity alignment tools.

This study identifies CDK12 condensates at nuclear speckles as a therapeutic target and demonstrates that cyclin K molecular glue degraders like HQY1428 disrupt these condensates, inhibiting oncogenic transcription and ovarian cancer growth.