Weihua Yue

The China Brain Multi-omics Atlas Project (CBMAP)

The China Brain Multi-omics Atlas Project (CBMAP) creates a comprehensive molecular reference map of over 1,000 human brains to address underrepresentation in East Asian populations and advance research on aging and neuropsychiatric disorders.

Deviations from normative functioning underlying emotional episodic memory revealed cross-scale neurodiverse alterations linked to affective symptoms in distinct psychiatric disorders

The paper identifies cross-scale neural alterations linked to affective symptoms in psychiatric disorders by comparing normative brain function with clinical data and linking these to specific cell types.

Cognitive Phenotype Shifts in Risk-Taking: Interplay of Non-Suicidal Self-Injury Behaviors and Intensified Depression

This study examines how non-suicidal self-injury (NSSI) interacts with depression severity in decision-making, finding that NSSI individuals are more risk-averse but show increased risk-taking as depression worsens.

Comparative genetic architectures of schizophrenia in East Asian and European populations

This study identifies schizophrenia genetic associations in East Asian and European populations, finding similar genetic effects across ancestries but highlighting challenges in polygenic risk prediction across groups.

Identification of novel risk loci with shared effects on alcoholism, heroin and methamphetamine dependence

This study identifies four genome-wide significant SNPs shared across alcoholism, heroin, and methamphetamine dependence and links them to gene expression and brain structure.

Childhood urbanization affects prefrontal cortical responses to trait anxiety and interacts with polygenic risk for depression

The paper examines how childhood urbanization affects prefrontal cortical responses to trait anxiety and interacts with polygenic depression risk in a genetically homogeneous population.