Qiang Chen

Scalable Hypothalamic Arcuate Neuron Differentiation from Human Pluripotent Stem Cells Suitable for Modeling Metabolic and Reproductive Disorders

This paper describes a scalable method to differentiate human pluripotent stem cells into hypothalamic arcuate neurons, which can model metabolic and reproductive disorders.

Modeling Friedreich's ataxia with Bergmann glia-enriched human cerebellar organoids

This paper develops a human cerebellar organoid model that recapitulates cerebellar development and reveals disease-specific phenotypes in Friedreich's ataxia.

Origin and functional impact of early nonlinearities in primate retina

The paper identifies two nonlinear mechanisms in primate retina that shape neural responses and improve modeling of visual function.

Dopamine and schizophrenia from bench to bedside: Discovery of a striatal co-expression risk gene set that predicts in vivo measures of striatal function.

The paper identifies a striatal gene set linked to schizophrenia risk that predicts in vivo dopamine synthesis and striatal activation in neurotypical and patient cohorts.

Childhood urbanization affects prefrontal cortical responses to trait anxiety and interacts with polygenic risk for depression

The paper examines how childhood urbanization affects prefrontal cortical responses to trait anxiety and interacts with polygenic depression risk in a genetically homogeneous population.

Planar cell polarity pathway and development of the human visual cortex

The paper identifies genetic associations with cortical surface area using PCA and GWAS, linking DAAM1 to visual cortex development through mitochondrial pathways and thalamocortical input.