Karen R. Gertz

Lipocalin-2-expressing red pulp macrophages link ischemic stroke to systemic immune reprogramming in mice and humans

Splenic Lcn2 is induced biphasically after mouse stroke and localizes to red pulp macrophages; recombinant LCN2 induces T cell and monocyte hyporesponsiveness and monocyte phagocytosis-ROS uncoupling, with human spleen support.

Mind the translational gap: human microglia differ from mouse microglia in their regulation of Kv and Kir2.1 channels

The paper compares Kv and Kir2.1 channel activity in human and mouse microglia, finding significant differences in their regulation and functional responses.

Brain-wide continuous functional ultrasound imaging for real-time monitoring of hemodynamics during ischemic stroke

This study uses functional ultrasound imaging to monitor hemodynamic changes in rat brains after ischemic stroke, revealing differences in ischemic lesion progression between two stroke models.

Lithium inhibits tryptophan catabolism via the inflammation-induced kynurenine pathway in human microglia

This study shows lithium inhibits the inflammatory kynurenine pathway in human microglia by reducing IDO1 activity through modulation of STAT1 and STAT3 phosphorylation.