Martin Holtkamp

This study compares the effects of AMPA receptor inhibitors on seizure-like events in murine and human brain slices, finding species-specific differences in drug efficacy.

The paper investigates electrical signaling between mid-capillary pericytes and endothelial cells in the neurovascular unit, showing syncytial coupling and its role in transmitting seizure-associated signals without relying on VGCCs.

This study examines the effects of LGI1 autoantibodies on human CA3 neurons using ex vivo slices, revealing increased neuronal activity and distinct mechanisms from potassium channel blockers.

The paper compares Kv and Kir2.1 channel activity in human and mouse microglia, finding significant differences in their regulation and functional responses.

The paper characterizes neuronal and synaptic diversity in human layer 2-3 pyramidal neurons across individuals, finding that neuronal physiology varies with laminar depth while synaptic properties are consistent.

This study shows NASPM inhibits NMDA receptors rather than CP-AMPARs in human brain tissue, challenging its use as a specific CP-AMPAR inhibitor and questioning its therapeutic potential.

The paper examines how beta oscillations in multisensory brain areas correlate with faster response times during audiovisual tasks, suggesting their role in enhancing sensory processing through selective attention.

This study shows lithium inhibits the inflammatory kynurenine pathway in human microglia by reducing IDO1 activity through modulation of STAT1 and STAT3 phosphorylation.