Author

Matthieu Giraud

InsermORCID 0000-0002-1208-9677Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Immunology· 2 Genomics· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:differential expression· 2 Organism:mouse· 2 Organism:rat· 2 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1 Research Focus:cell-cell communication· 1 Research Focus:chromatin & epigenetic regulation· 1

Frequent Co-Authors

Axel You· 2 shared Claire UsaliD· 2 shared Francine Padonou· 2 shared Ignacio AnegóniD· 2 shared Laurent TessoniD· 2 shared Marie Massoda· 2 shared Séverine MénoretiD· 2 shared C. Guyon· 1 shared

Activity by Year

2020-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 31 mutual co-author links

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2 shared papersImmunology

Axel You

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Author profile →

3 papers

Recent·Most cited

A PATHOGENIC NFKB2 VARIANT CAUSES COMBINED IMMUNODEFICIENCY WITH THYMIC AND PERIPHERAL LYMPHOID DEFECTS IN RATS

Séverine Remy, Laurent Tesson, Claire Usal, Marie Massoda, Séverine Ménoret, Irina Proekt, David Yu, Axel You, Matthieu Giraud, Mark Stuart Anderson, Ignacio Anegón

This study characterizes a rat model with a NFKB2 mutation, revealing systemic immunodeficiency with thymic and peripheral lymphoid defects.

bioRxiv · Oct 8, 2026 · PreprintImmunology

Cross-species chromatin accessibility pinpoints HIVEP3 as a driver of thymic epithelial maturation and self-antigen expression, preventing chronic inflammation

Sümeyye Yayilkan, Marie Massoda, Séverine Ménoret, Axel You, Lucas Brusselle, Claire Usal, Laurent Tesson, Mathieu Rouel, Flore Couzy, Francine Padonou, Cloé Zamit, Jérémy C. Santamaria, Pierre Maminirina, Olivier Baron, Jérôme Jullien, , Matthieu Giraud

This study identifies HIVEP3 as a critical regulator of thymic epithelial maturation and self-antigen expression, with its deficiency causing chronic inflammation.

bioRxiv · Jun 19, 2026 · PreprintImmunology

Aire-dependent genes undergo Clp1-mediated 3’UTR shortening associated with higher transcript stability in the thymus

C. Guyon, Nada Jmari, Francine Padonou, Yen-Chin Li, Olga Ucar, Noriyuki Fujikado, Fanny Coulpier, Christophe Blanchet, David E. Root, Matthieu Giraud

The paper identifies Clp1-mediated 3’UTR shortening as a post-transcriptional mechanism enhancing transcript stability of Aire-sensitive genes in thymic medullary epithelial cells.

eLife · Apr 27, 2020Peer-reviewedGenomics