Mark Stuart Anderson

This study characterizes a rat model with a NFKB2 mutation, revealing systemic immunodeficiency with thymic and peripheral lymphoid defects.

This study identifies novel SLE autoantigens and links EBV-driven immunity to autoimmunity through longitudinal PhIP-seq and machine learning analysis.

This study identifies altered purinergic signaling and CD8+ T cell dysregulation in STAT3 GOF syndrome, showing partial normalization with JAK inhibitors.

AEGIS identifies epitope- and clone-specific autoimmunity in ROHHAD by linking immune repertoires to self-epitopes, revealing convergence on ZSCAN1 epitopes in the CNS.

This study shows Fezf2 regulates mTEC lineage commitment and homeostasis, with transcriptional repression playing a key role in maintaining thymic epithelial populations.

This study identifies the role of Nr4a family nuclear receptors in transcriptional control of T cell tolerance during thymic development, showing their necessity for negative selection and anergy-like programs in self-reactive T cells.

This study identifies eQTLs in psoriatic skin that are modulated by local inflammation, showing that gene regulation is primarily influenced by skin-specific factors rather than systemic variables.

This study uses PhIP-Seq to identify novel autoantibodies in ILD patients, revealing a new molecular endotype associated with inflammation and fibrosis.

The paper uses single-cell RNA sequencing to analyze murine pancreatic duct cells, identifying heterogeneity and functional roles in disease progression.

The paper maps stimulation-responsive chromatin changes in immune cells and identifies variants linked to autoimmunity.

The paper identifies an IL2RA enhancer associated with autoimmunity using CRISPRa and shows it affects gene activation timing without blocking expression.