Andrew L. Lovering

A widespread bacterial toxin reveals a deeply divergent DNase family neutralized by diverse immunity proteins.

This study identifies Rehh as a widespread bacterial toxin with DNase activity, revealing its evolutionary divergence and mechanism of neutralization by immunity proteins.

Direct targeting of the WAVE-regulatory complex and the actin cytoskeleton by the Anaplasma phagocytophilum effector, AnkA

This study identifies AnkA as a bacterial effector that directly targets the WAVE Regulatory Complex and actin cytoskeleton, using molecular mimicry to subvert host cell functions during infection.

A Type VII-secreted toxin enables inter-mycobacterial competition

The paper identifies a type VII-secreted toxin in mycobacteria that enables inter-bacterial competition by targeting arabinogalactan.

A C-terminal Processing Protease Implicated in Flagellin Turnover and Developmental Progression in a Bacterial Predator

This study identifies Bd0967 as a C-terminal processing protease in Bdellovibrio bacteriovorus that degrades flagellins and regulates developmental progression.

TipA, a Bdellovibrio bacteriovorus BPI-like double-TULIP is opened by its adapter protein, TipB

This paper characterizes TipA and TipB, two proteins from Bdellovibrio bacteriovorus, showing TipA's lipid-binding structure and TipB's role in inducing conformational changes in TipA.

PNGaseA-mediated N-glycan stripping from peptides by infant-derived Bifidobacterium bifidum

This paper characterizes a PNGaseA enzyme from Bifidobacterium bifidum that preferentially strips N-glycans from peptides over proteins, revealing its structural basis for substrate specificity.

Bacterial sirtuin CobB and PRPP synthase crosstalk in the regulation of protein acetylation in Escherichia coli

This study shows that CobB and PRPP synthase form a complex that regulates protein acetylation and deacetylation in E. coli, impacting metabolism and cellular pathways.