Hao Ming

The paper develops a serum-free 6iL/E4 culture system that enables derivation and maintenance of embryonic stem cells (ESCs) across multiple mammalian species, revealing conserved mechanisms for ESC self-renewal.

This study investigates mRNA translation dynamics during mouse pre-implantation development, revealing novel mechanisms of translational selectivity and the role of Eif1ad3 in ribosome biogenesis.

This paper identifies METTL7A as a gene that enhances bovine IVF embryo development by reducing oxidative stress and mitochondrial damage.

This study establishes a method to derive and culture bovine extraembryonic endoderm cells (bXENs) using a chemical cocktail, revealing their role in maintaining stemness and supporting embryo development.

The paper maps the single-cell transcriptomes of bovine peri-implantation development to identify cell lineages and molecular mechanisms involved in early pregnancy success and failure.

The paper uses single-cell transcriptomics to compare bovine blastocysts cultured in vivo versus in vitro under different conditions, revealing how culture affects cell lineage and metabolism.

The paper develops a method to generate bovine blastocyst-like structures (blastoids) from stem cells, which mimic blastocysts in morphology and transcriptomes.

This study uses a chemical cocktail to derive and culture bovine trophoblast stem cells, which retain developmental potency.

This study uses low-input ribosome profiling to analyze translational selectivity in bovine oocytes and preimplantation embryos, revealing four modes of translational regulation and their temporal dynamics.

This study shows that the Hira complex is essential for oocyte developmental competence by maintaining transcriptional silencing through H3.3 deposition and chromatin modifications.

This study examines chromatin accessibility and gene expression in cardiac fibroblasts before and after myocardial infarction using ATAC-seq and RNA-seq, revealing correlations between promoter accessibility and gene expression, and identifying potential transcription factors involved in differential gene expression.