Deborah R. Winter

The paper identifies four distinct synovial macrophage populations in RA models and shows conserved inflammatory responses across conditions.

The paper identifies immune cell populations and gene expression differences associated with non-inflammatory pain in RA patients using flow cytometry and single-cell RNA-seq.

This study uses scRNA-seq to show that Tcf21 is essential for Foxd1+ stromal progenitor differentiation during kidney development, with loss of Tcf21 causing stromal subpopulation depletion and emergence of Emcn-expressing cells.

The paper identifies three subpopulations of tissue-resident monocyte-lineage cells in inflammatory arthritis and examines their origins and responses to synovial disruption.

This study presents lineage tracing results from 18 myeloid-specific fate-mapping models in mouse peripheral blood and synovial tissue, validating synovial macrophage identification through flow cytometry and CITE-seq.

This study shows that deleting Ikkβ in esophageal epithelial cells worsens eosinophilic esophagitis in a mouse model, highlighting the importance of IKKβ/NFκB signaling in preventing allergic inflammation.

This study identifies distinct TNF-dependent aging signatures in monocyte subpopulations, showing that aging affects their transcriptional regulation differently.

This study identifies three monocyte transcriptional subgroups in SSc patients that correlate with disease activity, particularly lung function.

This study shows AOAH and TLR4 regulate microglial activation and pelvic pain in IC/BPS by linking gut microbiota to CNS immune responses.

This paper uses machine learning to predict the virulence of Pseudomonas aeruginosa isolates based on genomic data, achieving 75% accuracy using random forest models.

Single-cell RNA-seq of lung tissue from transplant donors, fibrosis patients, and a living patient identifies cell type-specific disease-associated molecular pathways in pulmonary fibrosis.

The paper identifies longitudinal transcriptional changes in TBI-associated microglia linked to synaptic weakening, highlighting genes like Ptpn5, Shank3, and Sqstm1.