Author

Axel Hyrenius Wittsten

University of California, San FranciscoORCID 0000-0002-1239-4954Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Bioengineering· 1 Synthetic Biology· 1

Signature Assays, Organisms & Methods

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Research Focus:drug response / drug discovery· 2 Approach:experimental assay· 2 Organism:human· 2 Research Focus:cell type annotation· 1 Research Focus:gene regulatory network inference· 1 Research Focus:protein design· 1

Frequent Co-Authors

Iowis ZhuiD· 2 shared Julie M. GarciaiD· 2 shared Kole T. RoybaliD· 2 shared Ahmad S. KhaliliD· 1 shared Alejandro Chaves-Martinez· 1 shared Bin LiuiD· 1 shared Brian Rudolph ShyiD· 1 shared Chloë Thienpont· 1 shared

Activity by Year

2022-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 33 mutual co-author links

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2 shared papersBioengineering

Iowis ZhuORCID

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2 papers

Recent·Most cited

BioengineeringbioRxivPreprintJan 23, 2026

Synthetic Hybrid Receptors for Safer and Programmable T Cell Therapy

Maxwell Gabriel Foisey, Julie M. Garcia, Xun Li…·Kole T. Roybal

This paper introduces Hybrid Receptors (Hybrid-Rs) to improve T cell therapy safety and programmability by combining CAR and SNIPR features for controlled gene regulation and reduced toxicity.

DOI 10.64898/2026.01.22.701150

humanexperimental assay

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Synthetic BiologyCellPeer-reviewedApr 1, 2022

Design and modular assembly of synthetic intramembrane proteolysis receptors for custom gene regulation in therapeutic cells

Iowis Zhu, Raymond Liu, Julie M. Garcia…·Kole T. Roybal

This paper designs and demonstrates synthetic receptors for tunable gene regulation in therapeutic cells, enabling customizable and clinical-ready gene control.

202 citationstop 1%

humanexperimental assay

𝕏 PostBluesky