Synthetic Hybrid Receptors for Safer and Programmable T Cell Therapy
Maxwell Gabriel Foisey, Julie M. Garcia, Xun Li, Xiaoyu Yang, Claire E. Hilburger, Chloë Thienpont, Alejandro Chaves-Martinez, Serkan Belkaya, Tina Truong, Iowis Zhu, Raymond Liu, Axel Hyrenius Wittsten, Ricardo Almeida, Brian Rudolph Shy, Greg M. Allen, , Kole T. Roybal
This paper introduces Hybrid Receptors (Hybrid-Rs) to improve T cell therapy safety and programmability by combining CAR and SNIPR features for controlled gene regulation and reduced toxicity.
bioRxiv · Jan 23, 2026 · PreprintBioengineering