Kole T. Roybal

This paper develops 4-1BB-targeting lentiviral vectors to selectively expand and transduce antigen-specific T cells, enhancing their function in cancer immunotherapy.

This paper identifies methods to achieve ultra-large DNA integrations (>10 kb) in human cells with high efficiency using optimized templates and delivery strategies.

This paper introduces Hybrid Receptors (Hybrid-Rs) to improve T cell therapy safety and programmability by combining CAR and SNIPR features for controlled gene regulation and reduced toxicity.

This paper introduces SNIPR, a synthetic receptor that responds to soluble ligands, enabling targeted CAR T-cell therapy and synthetic cell signaling.

The paper designs EndoTags to trigger endocytosis and degradation of target proteins, enabling tissue-specific targeting and therapeutic applications.

This paper designs synthetic gene regulatory programs for human cells that can be controlled by FDA-approved drugs and demonstrate therapeutic applications in immune cells.

This paper develops a PET imaging system using engineered T cells that report antigen recognition through inducible reporter gene expression, showing enhanced signal in antigen-expressing tumors.

This paper designs and demonstrates synthetic receptors for tunable gene regulation in therapeutic cells, enabling customizable and clinical-ready gene control.