Design and modular assembly of synthetic intramembrane proteolysis receptors for custom gene regulation in therapeutic cells
Iowis Zhu, Raymond Liu, Julie M. Garcia, Axel Hyrenius Wittsten, Dan Ilya Piraner, Josef Alavi, Divya V. Israni, Bin Liu, Ahmad S. Khalil, Kole T. Roybal
This paper designs and demonstrates synthetic receptors for tunable gene regulation in therapeutic cells, enabling customizable and clinical-ready gene control.
Cell · Apr 1, 2022Peer-reviewedSynthetic Biology