Author

Z. Begum Yagci

North Carolina State UniversityORCID 0000-0002-1239-8680Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Biochemistry· 1 Cell Biology· 1 Developmental Biology· 1

Signature Assays, Organisms & Methods

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Organism:human· 3 Research Focus:cell type annotation· 2 Approach:experimental assay· 2 Assay:scRNA-seq· 2 Research Focus:clustering· 1 Research Focus:differential expression· 1 Research Focus:drug response / drug discovery· 1 Organism:mouse· 1

Frequent Co-Authors

Albert J. KeungiD· 3 shared Dilara SeniD· 2 shared Linna HaniD· 2 shared Gautami R Kelkar· 1 shared Jeremy M. SimoniD· 1 shared Jessica K. HartmaniD· 1 shared Lexi Land· 1 shared R. Chris EstridgeiD· 1 shared

Activity by Year

2024-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 30 mutual co-author links

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3 shared papersCell Biology

Albert J. KeungORCID

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3 papers

Recent·Most cited

A Human Angelman Syndrome Class II Pluripotent Stem Cell line with Fluorescent Paternal UBE3A Reporter

Gautami R Kelkar, Samantha R. Stuppy, Dilara Sen, Z. Begum Yagci, Linna Han, Lexi Land, Jessica K. Hartman, Albert J. Keung

This paper develops a human pluripotent stem cell line with a fluorescent UBE3A reporter to monitor paternal UBE3A expression during neuronal maturation and test reactivation strategies.

Frontiers in Cell and Developmental Biology · Aug 29, 2025Peer-reviewedCell Biology

A High Sensitivity Assay of UBE3A Ubiquitin Ligase Activity

Linna Han, Z. Begum Yagci, Albert J. Keung

This paper develops a fast, sensitive assay for measuring UBE3A ubiquitin ligase activity using fluorescence detection, suitable for preclinical and clinical applications.

Methods · Feb 9, 2025Peer-reviewedBiochemistry

Loss of UBE3A impacts both neuronal and non-neuronal cells in human cerebral organoids

R. Chris Estridge, Z. Begum Yagci, Dilara Sen, Travis Ptacek, Jeremy M. Simon, Albert J. Keung

This study shows that UBE3A loss affects both neuronal and non-neuronal cells in human cerebral organoids, altering cell composition and transcriptomes.

bioRxiv · Feb 9, 2024 · PreprintDevelopmental Biology