Albert J. Keung

This paper demonstrates the use of colloidal DNA/RNA nanoaggregates for data storage and obfuscation by encoding digital information into oligo libraries and manipulating ionic strength.

This study shows that glucose levels affect the growth, structure, and cell types in human cerebral organoids, with physiological glucose altering lineage distributions and requiring mTOR inhibition to restore neurodevelopmental cell types.

This paper develops a human pluripotent stem cell line with a fluorescent UBE3A reporter to monitor paternal UBE3A expression during neuronal maturation and test reactivation strategies.

This paper develops a fast, sensitive assay for measuring UBE3A ubiquitin ligase activity using fluorescence detection, suitable for preclinical and clinical applications.

The paper introduces a new soft decoder for nanopore sequencing that improves throughput and read density while maintaining low error rates for DNA and RNA.

This study shows that UBE3A loss affects both neuronal and non-neuronal cells in human cerebral organoids, altering cell composition and transcriptomes.

REMY is a platform for analyzing histone modifications in yeast, demonstrating its utility in studying acetylation specificity and antibody performance.

This study quantifies the maximum information transfer across a promoter using epigenome editing and shows that chromatin state can tune gene expression and transfer functions.

This paper introduces a dynamic DNA-based information storage system using a hybrid toehold structure, improving storage density and enabling non-destructive file access.

The paper introduces CRATES, a one-step method to assemble large CRISPR arrays, demonstrating its utility for multiplexed gene editing and revealing design constraints.