Ivo Müeller

The paper identifies and characterizes two novel Plasmodium vivax merozoite proteins, PvMP45 and PvMP36, which bind reticulocyte receptors and are targets of protective antibodies, suggesting their potential as vaccine candidates.

This paper develops a cost-effective MinION sequencing assay to detect G6PD deficiency SNPs in malaria-endemic regions, showing high reliability and concordance with Sanger sequencing.

The paper determines the cryo-EM structure of the Plasmodium falciparum Pfs230-Pfs48/45 fertilization complex and identifies domains critical for function and vaccine design.

This study evaluates how genetic diversity in Plasmodium vivax antigens affects serological markers for malaria exposure and finds that using multiple antigens can improve detection accuracy.

This study identifies IgM as a key antibody isotype in immune responses against Plasmodium falciparum gametocytes, showing its superior complement fixation activity compared to IgG.

The paper develops a molecular barcode and online tool to identify and map imported Plasmodium vivax infections using SNP analysis and machine learning.

VIVID is a web tool that visualizes and interprets DNA variants in 3D on protein models to study genetic variation and its association with phenotypes.

This study uses single-cell RNA sequencing to analyze P. vivax sporozoites, identifying stage-specific transcriptomic signatures and gene usage patterns distinct from P. falciparum.

The paper analyzes global population genomics of two C. hominis subspecies over 500 years, identifying divergence, transmission patterns, and introgression between them.

This study demonstrates that Nanopore sequencing provides accurate SNV calls and detects structural variants in malaria parasite genomes, comparable to Illumina sequencing, and enables real-time, field-deployable whole genome sequencing.

This study identifies five genome-wide associations with severe malaria risk in 17,000 individuals from Africa, Asia, and Oceania, including a new variant linked to cerebral malaria.

The paper generates a genome from a historical European Plasmodium vivax strain, revealing its evolutionary relationship to American strains and the presence of drug resistance variants predating their use.

This study characterizes the transcriptome and histone epigenome of Plasmodium vivax sporozoites, revealing transcriptional and post-transcriptional control mechanisms and potential pathways for hypnozoite formation.

The paper identifies and validates a panel of 8 P. vivax proteins whose IgG antibody responses can detect recent exposure to P. vivax infections within the prior 9 months with 80% sensitivity and specificity.

The paper develops isoRelate, an IBD analysis method for haploid pathogens, identifies selection signals and population structure in Plasmodium falciparum data.

This study identifies kelch13 mutations associated with artemisinin resistance in Southeast Asia and finds low frequency of these mutations in Africa, suggesting different evolutionary pressures.