Author

Sébastien Rubin

InsermORCID 0000-0002-1246-0712Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Genetic & Genomic Medicine· 1 Neuroscience· 1 Pathology· 1

Signature Assays, Organisms & Methods

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Assay:bulk RNA-seq· 2 Approach:experimental assay· 2 Organism:mouse· 2 Approach:statistical model· 2 Research Focus:development & morphogenesis· 1 Research Focus:differential expression· 1 Assay:DNA methylation· 1 Research Focus:drug response / drug discovery· 1

Frequent Co-Authors

Cécile DuplàaiD· 2 shared Claire R. PeghaireiD· 2 shared Juliette Vaurs· 2 shared Romain BoulestreauiD· 2 shared Thierry CouffinhaliD· 2 shared Abigail C. LayiD· 1 shared Alexandre BoyeriD· 1 shared Amber EmmettiD· 1 shared

Activity by Year

2024-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 23 mutual co-author links

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2 shared papersPathology

Cécile DuplàaORCID

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3 papers

Recent·Most cited

Genetic & Genomic MedicinemedRxivPreprintJan 17, 2026

Integrative kidney multi-omics traces genetic drivers of chronic kidney disease to targets within the renal epigenome, transcriptome and proteome

Amber Emmett, Xiaoguang Xu, Xiao Jiang…·Maciej Tomaszewski

The paper identifies 508 CKD-associated genetic loci, prioritizes 651 kidney genes, and highlights novel CKD genes like CA12 with functional consequences.

1 citation

humanDNA methylation

PathologybioRxivPreprintMar 24, 2025

Strain Matters: The 129S1/SvlmJ Mouse Model Reveals the Genetic and Inflammatory Susceptibility to Hypertensive Complications

Arthur Orieux, Romain Boulestreau, Marie‐Lise Bats…·Sébastien Rubin

This study compares two mouse strains to show that genetic background affects susceptibility to hypertensive complications, with 129S1/SvlmJ mice showing more severe organ damage and inflammation.

DOI 10.1101/2025.03.24.641145

mousebulk RNA-seq

NeurosciencebioRxivPreprintOct 8, 2024

Cerebral Small Vessel Disease genetic determinant TRIM47 controls brain homeostasis via the NRF2 antioxidant system

Cécile Duplàa, Valentin Delobel, Romain Boulestreau…·Claire R. Peghaire

This study identifies TRIM47 as a genetic determinant of cerebral small vessel disease, showing it regulates brain homeostasis through the NRF2 antioxidant pathway by stabilizing NRF2 protein levels.

3 citations

mousebulk RNA-seq