Thierry Couffinhal

This study compares two mouse strains to show that genetic background affects susceptibility to hypertensive complications, with 129S1/SvlmJ mice showing more severe organ damage and inflammation.

This study identifies TRIM47 as a genetic determinant of cerebral small vessel disease, showing it regulates brain homeostasis through the NRF2 antioxidant pathway by stabilizing NRF2 protein levels.

This study shows that DLL4-NOTCH1 signaling between astrocytes promotes neuroinflammation through the IL-6-STAT3 axis, and blocking DLL4 reduces experimental autoimmune encephalomyelitis symptoms.

This study shows that BBB disruption triggers a secondary barrier at the Glia Limitans via astrocytic response, reducing disease severity in multiple sclerosis.