Strain Matters: The 129S1/SvlmJ Mouse Model Reveals the Genetic and Inflammatory Susceptibility to Hypertensive Complications
Arthur Orieux, Romain Boulestreau, Marie‐Lise Bats, Maxime Michot, Alexandre Boyer, Virginie Dinet, Juliette Vaurs, Pascale Dufourcq, Claire R. Peghaire, Cécile Duplàa, Thierry Couffinhal, Sébastien Rubin
This study compares two mouse strains to show that genetic background affects susceptibility to hypertensive complications, with 129S1/SvlmJ mice showing more severe organ damage and inflammation.
bioRxiv · Mar 24, 2025 · PreprintPathology