Claire R. Peghaire

This paper develops a thrombus-on-chip model with endothelium and whole blood to study thrombosis, showing TNF-activation increases platelet adhesion and fibrin deposition.

This study compares two mouse strains to show that genetic background affects susceptibility to hypertensive complications, with 129S1/SvlmJ mice showing more severe organ damage and inflammation.

This study identifies TRIM47 as a genetic determinant of cerebral small vessel disease, showing it regulates brain homeostasis through the NRF2 antioxidant pathway by stabilizing NRF2 protein levels.