NeuroscienceStem Cell ReportsPeer-reviewed
Granulin Loss of Function in Human Mature Brain Organoids Implicates Astrocytes in TDP-43 Pathology
Martina de Majo, Mark Koontz, Elise Marsan…·Erik M. Ullian
The paper shows that loss of GRN in human brain organoids leads to TDP-43 pathology, driven by astrocytes, and can be rescued by progranulin.
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