Author

Kyounghee Seo

University of California, San Francisco

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

Click to filter author papers

Genomics· 2 Cancer Biology· 1 Neuroscience· 1

Signature Assays, Organisms & Methods

Click to filter · or open tag

Approach:experimental assay· 4 Research Focus:cell-cell communication· 3 Research Focus:differential expression· 3 Research Focus:drug response / drug discovery· 3 Organism:human· 3 Organism:mouse· 3 Assay:bulk RNA-seq· 2 Research Focus:cell type annotation· 2

Frequent Co-Authors

David Ronan RaleighiD· 3 shared Mitchel Stuart BergeriD· 3 shared Tomoko OzawaiD· 3 shared Jacob S. YoungiD· 2 shared Joanna J. PhillipsiD· 2 shared Joanna Pak· 2 shared Kanish MirchiaiD· 2 shared Siyuan John LiuiD· 2 shared

Activity by Year

2023-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 41 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

3 shared papersGenomics

David Ronan RaleighORCID

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

IL-6 underlies microenvironment immunosuppression and resistance to therapy in glioblastoma

Jacob S. Young, Nam Woo Cho, Calixto‐Hope G. Lucas, Hinda Najem, Kanish Mirchia, William C. Chen, Courtney M. Tamaki, Harrshavasan Congivaram, Kyounghee Seo, Naomi Zakimi, Vikas Daggubati, Tim Casey-Clyde, Minh P. Nguyen, Zhenhong Chen, Joanna J. Phillips, , David Ronan Raleigh

This study identifies IL-6 as a driver of immunosuppression in glioblastoma, showing that its inhibition enhances response to immune checkpoint therapy and radiotherapy in preclinical models.

Cancer Research · Apr 13, 2026Peer-reviewedCancer Biology

In vivo perturb-seq of cancer and microenvironment cells dissects oncologic drivers and radiotherapy responses in glioblastoma

Siyuan John Liu, Christopher Zou, Joanna Pak, A. P. Morse, Dillon Pang, Timothy Casey-Clyde, Ashir A. Borah, David Wu, Kyounghee Seo, Thomas O’Loughlin, Daniel A. Lim, Tomoko Ozawa, Mitchel Stuart Berger, Roarke A. Kamber, William A. Weiss, , Luke A. Gilbert

This study uses in vivo perturb-seq to analyze gene function and radiotherapy responses in glioblastoma by targeting cancer and microenvironment cells.

Genome biology · Oct 7, 2024Peer-reviewedGenomics

Multiplatform molecular profiling and functional genomic screens identify prognostic signatures and mechanisms underlying MEK inhibitor response in somatic NF1 mutant glioblastoma

Sixuan Pan, Kanish Mirchia, Emily Payne, Siyuan John Liu, Nadeem N. Al-Adli, Zain Peeran, Poojan D. Shukla, Jacob S. Young, Rohit K. Gupta, Jasper Wu, Joanna Pak, Kyounghee Seo, Tomoko Ozawa, Brian S Na, Alyssa Terry Reddy, , Harish N. Vasudevan

bioRxiv · Jul 1, 2024 · PreprintGenomics

Granulin Loss of Function in Human Mature Brain Organoids Implicates Astrocytes in TDP-43 Pathology

Martina de Majo, Mark Koontz, Elise Marsan, Nir Salinas, Marina Ramsey, Yien–Ming Kuo, Kyounghee Seo, Huinan Li, Nina M. Dräger, Kun Leng, Santiago L. Gonzales, Michael Kurnellas, Yuichiro Miyaoka, Joseph R. Klim, Martin Kampmann, , Erik M. Ullian

The paper shows that loss of GRN in human brain organoids leads to TDP-43 pathology, driven by astrocytes, and can be rescued by progranulin.

Stem Cell Reports · Feb 23, 2023Peer-reviewedNeuroscience