BiochemistrybioRxivPreprint
Suppression of ITPK1 and IPMK activities impairs mTORC1 signaling due to accelerated signal termination and prevents pancreatic β-cell metabolic adaptation to excess glucose
Clarisse Iradukunda, E. Alan Salter, Dilipkumar Uredi…·Lucia E. Rameh
This study shows that reducing ITPK1 and IPMK activities lowers IP5 levels, which shortens mTORC1 signaling and hinders β-cell metabolic adaptation to high glucose.
DOI 10.64898/2026.03.04.709646