Xiaodong Wang

This study identifies the host soluble inositol phosphate pathway as critical for coronavirus replication and demonstrates a multi-target inhibitor that effectively suppresses viral replication in cells and mice.

This study shows that reducing ITPK1 and IPMK activities lowers IP5 levels, which shortens mTORC1 signaling and hinders β-cell metabolic adaptation to high glucose.

This study identifies a host-directed adjuvant, KL1, that increases intracellular bacterial energy and sensitizes persisters to antibiotics by modulating host immune responses and reducing reactive species production.

This study designs, synthesizes, and characterizes a new class of IPMK kinase inhibitors, showing reduced glioblastoma cell growth and a novel InsP5 metabolic signature.

The paper compiles an annotated set of 171 small molecule modulators targeting 98 novel AD therapeutic proteins, serving as chemical tools for hypothesis validation.