The epigenetic eraser LSD1 lies at the apex of a reversible erythroid to myeloid cell fate decision
Lei Yu, Greggory Myers, Chia-Jui Ku, Emily Schneider, Yu Wang, Sharon A Singh, Natee Jearawiriyapaisarn, Andrew D. White, Takashi Moriguchi, Rami N. Khoriaty, Masayuki P. Yamamoto, M. Geoffrey Rosenfeld, Julien Pedron, John Hackett Bushweller, Kim-Chew Lim, James Douglas Engel
This study shows that LSD1 promotes erythropoiesis by repressing myeloid fate, and inhibiting myeloid factors reverses lineage conversion caused by LSD1 inactivation in mice and human HSPC.
bioRxiv · Jan 13, 2021 · PreprintDevelopmental Biology