Author

Luca Primo

Candiolo Cancer InstituteORCID 0000-0002-1294-0441Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Research Focus:drug response / drug discovery· 2 Organism:human· 2 Assay:bulk RNA-seq· 1 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell type annotation· 1 Research Focus:clustering· 1 Research Focus:differential expression· 1 Approach:experimental assay· 1

Frequent Co-Authors

Alberto PuliafitoiD· 2 shared Andrea BertottiiD· 2 shared Elena GrassiiD· 2 shared Federica GalvagnoiD· 2 shared Letizia Pizzini· 2 shared Sabrina Johanna FletcheriD· 2 shared Andrea PirasiD· 1 shared Antonio CelaniiD· 1 shared

Activity by Year

2026-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 41 mutual co-author links

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2 shared papersCancer Biology

Alberto PuliafitoORCID

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2 papers

Recent·Most cited

Cancer BiologyCell Reports MethodsPeer-reviewedAug 17, 2026

Inference of lineage hierarchies, growth and drug response mechanisms in cancer cell populations without tracking

Andrea Piras, Federica Galvagno, Letizia Pizzini…·Alberto Puliafito

This study introduces a method to infer lineage hierarchies and drug response mechanisms in cancer cell populations without single-cell tracking, demonstrating its effectiveness through simulations and experiments.

DOI 10.1016/j.crmeth.2026.101566

humanbulk RNA-seq

𝕏 PostBluesky

Cancer BiologybioRxivPreprintJun 8, 2026

TGF-β1-induced differentiation enhances chemotherapy response in metastatic colorectal cancer organoids

Sabrina Johanna Fletcher, Letizia Pizzini, Irene Catalano…·Alberto Puliafito

This study shows that TGF-β1-induced differentiation in colorectal cancer organoids enhances chemotherapy response by reducing clonogenic capacity and increasing oxaliplatin cytotoxicity.

DOI 10.64898/2026.06.04.730067

humanscRNA-seq

𝕏 PostBluesky